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Leslie Gunatilaka

Professor; Director, Natural Products Center

Publication:

Zhan J, Gunatilaka AA. Aug 2008. Microbial metabolism of 1-aminoanthracene by Beauveria bassiana. Bioorg Med Chem, 16:5085-9

Abstract

The carcinogen and mutagen, 1-aminoanthracene, was efficiently metabolized by the fungal strain Beauveria bassiana ATCC 7159 to yield three new metabolites identified as 1-acetamido-5-[(4'-O-methyl-beta-d-glucopyranosyl)oxy]anthracene, 1-acetamido-8-[(4'-O-methyl-beta-d-glucopyranosyl)oxy]anthraquinone, and 1-acetamido-6-[(4'-O-methyl-beta-d-glucopyranosyl)oxy]anthraquinone, together with 1-acetamidoanthracene and 1-acetamidoanthraquinone. Formation of these metabolites suggests that the metabolic pathways of 1-aminoanthracene in B. bassiana ATCC 7159 involve acetylation, oxidation, hydroxylation, and O-methylglucosylation.

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