A (Jay) J Gandolfi

Associate Dean, Pharmacy Research and Graduate Affairs

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Research Interests

My research interests are in the molecular and cellular mechanisms of toxicity. Current studies concentrate on the use of in vitro systems to evaluate cell specific injury. Specific studies examine the effects of low level metal exposure on cell signaling and gene expression and the development of in vitro models to reflect in vivo toxicity. Tissues of interest are the liver, kidney, and prostate.

Selected Publications

. Aug 2008. The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: acute studies. Toxicology, 250:47-54

. Jun 2008. Immortalized human urothelial cells as a model of arsenic-induced bladder cancer. Toxicology, 248:67-76

. Aug 2008. Epigenetic remodeling during arsenical-induced malignant transformation. Carcinogenesis, 29:1500-8

Catania JM, Pershing AM, Gandolfi AJ. Aug 2007. Precision-cut tissue chips as an in vitro toxicology system. Toxicol In Vitro, 21:956-61