Graduate Training in Toxicology and Toxicogenomics

Camenisch, Todd: The focus of the laboratory is investigating the integration between extracellular matrix and growth factor receptor signaling during heart morphogenesis. The emphasis is upon heart septae and valve formation. We have established that hyaluronan, a matrix sugar, is able to modulate receptor tyrosine kinase activity during early heart valve morphogenesis. We believe the EGFR family of receptors and cognate ligands play integral functions during heart development. This growth factor signaling activity is most likely context specific in regards to matrix components, proteases, and growth factor presence. Thus experimental approaches are designed to decipher this complex developmental process.

• Departmental affiliations: Pharmacology & Toxicology, Molecular & Cellular Biology, BIO5 Institute
• Program affiliations: Pharmacology & Toxicology, Molecular and Cellular Biology, Graduate Training in Toxicology and Toxicogenomics