Cell Biology

Gordon, Herman: Research includes using a muscle cell culture model in which we can observe the aggregation of known synaptic molecules in response to neurons or active factors such as neural agrin. There appear to be 2 basic pathways which regulate the aggregation of synaptic molecules: one involves signal transduction and tyrosine phosphorylation while the other may involve structural interactions on the extracellular surface. When observed in detail, the aggregation is quite dynamic in surprising ways that we hope will promote a better understanding of the underlying processes & nbsp; Future research will hope to answer the question of how one synapse gets larger at the expense of the other.

• Departmental affiliations: Cellular & Molecular Medicine, Molecular & Cellular Biology
• Program affiliations: Cell Biology & Anatomy, Neuroscience, Biochemistry and Molecular & Cellular Biology

Klewer, Scott: Current research involves understanding the development of the human heart in order to understand at what point the heart can begin to develop abnormally. Of particular concern are babies who are born with Down syndrome as nearly half of these babies also are born with significant heart defects.

• Departmental affiliations: Cellular & Molecular Medicine, Pediatrics
• Program affiliations: Cell Biology & Anatomy

Lantz, R. Clark: Pulmonary toxicology

• Departmental affiliations: Cellular & Molecular Medicine, BIO5 Institute, Arizona Cancer Center, Community, Environment and Policy, College of Public Health
• Program affiliations: Cell Biology & Anatomy, Pharmacology & Toxicology, Advanced Research Institute for Biomedical Imaging (ARIBI), Public Health

McCuskey, Robert: Microcirculation; in vivo microscopy; Liver Pathobiology

• Departmental affiliations: Cellular & Molecular Medicine, Pediatrics
• Program affiliations: Cell Biology & Anatomy, Physiological Sciences