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Computational Biology

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An, Lingling :
Christensen, Thomas: The neural mechanisms involved in perceiving and interpreting spoken language provide a rich source of research questions that are central to understanding human communication. My research involves the use of state-of-the-art brain-mapping methods like functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) to study the neuroanatomical and functional organization of brain networks involved in auditory language processing. Research projects that students participate in involve the cognitive modulation of primary language processing by attention and memory networks, effects of attention type and cognitive load on language perception, and the roles of cortical-subcortical interactions in serving these cognitive processes. Students have opportunities to participate in experimental design, stimulus creation, data acquisition and statistical analysis of both behavioral and neurobiological data. Current experiments are a prelude to studying clinical populations with brain disorders that may disrupt language, verbal memory, attention, or any combination of these skills.
Cordes, Matthew: Protein folding; Structural evolution of proteins; NMR spectroscopy; Evolution of Cro proteins.
Dornhaus, Anna: Organization in groups, how collective behaviors emerge from the actions and interactions of individuals, is the main interest of Anna Dornhaus. As model systems she studies social insect colonies (bumble bees, honey bees and ants) in the laboratory and in the field, as well as using mathematical and individual-based modeling approaches. She investigates mechanisms of coordination in foraging, collective decision-making, task allocation and division of labor. Her recent work has included the role of communication in the allocation of foragers to food sources; the evolution of different recruitment systems in different species of bees, and how ecology shapes these recruitment systems; house hunting strategies in ants; speed-accuracy trade offs in decision-making; and whether different group sizes necessitate different organizational strategies. Please check my homepage for details on individual projects.
Ferriere, Regis: Interplay between adaptive trait evolution and ecological interactions. Mathematical foundations of adaptive dynamics modelling. Empirical testing using clonal microarthropods and lizards.
Gordon, Herman: Research includes using a muscle cell culture model in which we can observe the aggregation of known synaptic molecules in response to neurons or active factors such as neural agrin. There appear to be 2 basic pathways which regulate the aggregation of synaptic molecules: one involves signal transduction and tyrosine phosphorylation while the other may involve structural interactions on the extracellular surface. When observed in detail, the aggregation is quite dynamic in surprising ways that we hope will promote a better understanding of the underlying processes & nbsp; Future research will hope to answer the question of how one synapse gets larger at the expense of the other.
Henderson, David: Statistical applications to genomic and genetic data. Specifically, the development of novel statistical methods for the analysis of DNA microarray experiments and QTL analysis.
Higgins, Charles : Biologically-inspired engineering and computational neuroscience.

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