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Pharmacology

Faculty:

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Camenisch, Todd: The focus of the laboratory is investigating the integration between extracellular matrix and growth factor receptor signaling during heart morphogenesis. The emphasis is upon heart septae and valve formation. We have established that hyaluronan, a matrix sugar, is able to modulate receptor tyrosine kinase activity during early heart valve morphogenesis. We believe the EGFR family of receptors and cognate ligands play integral functions during heart development. This growth factor signaling activity is most likely context specific in regards to matrix components, proteases, and growth factor presence. Thus experimental approaches are designed to decipher this complex developmental process.
Chen, Qin: Molecular mechanisms of oxidative injury and adaptation; stress signal transduction pathways; genomics and proteomics of stress response; cytoprotective agents
Cherrington, Nathan: Transporter Regulation and Molecular Toxicology
Christensen, Thomas: The neural mechanisms involved in perceiving and interpreting spoken language provide a rich source of research questions that are central to understanding human communication. My research involves the use of state-of-the-art brain-mapping methods like functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) to study the neuroanatomical and functional organization of brain networks involved in auditory language processing. Research projects that students participate in involve the cognitive modulation of primary language processing by attention and memory networks, effects of attention type and cognitive load on language perception, and the roles of cortical-subcortical interactions in serving these cognitive processes. Students have opportunities to participate in experimental design, stimulus creation, data acquisition and statistical analysis of both behavioral and neurobiological data. Current experiments are a prelude to studying clinical populations with brain disorders that may disrupt language, verbal memory, attention, or any combination of these skills.
French, Edward: Neuropharmacology of drugs of abuse and addiction
Gandolfi, A (Jay): Toxicology of metals and halogenated solvents. In vitro toxicology.
Gillies, Robert: The Tumor Microenvironment, Anti-Cancer Therapies, and Molecular Imaging
Halonen, Marilyn: Immunopharmacology; cytokine regulation of IgE levels; cell biology effects of naturally occurring polymorphisms in cytokine genes related to asthma or allergy in humans; immune response development in infancy in relation to respiratory viruses and allergen and microbial exposures.

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