The BIO5 Institute

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Biomaterials

Faculty:

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Aspinwall, Craig: Development of Novel Methodologies for Investigations of Cellular Signal Transduction - Analytical Chemistry, Bioanalytical Chemistry, Biological Chemistry, Biophysics, Cell Physiology, Sensors, Instrumentation
Camenisch, Todd: The focus of the laboratory is investigating the integration between extracellular matrix and growth factor receptor signaling during heart morphogenesis. The emphasis is upon heart septae and valve formation. We have established that hyaluronan, a matrix sugar, is able to modulate receptor tyrosine kinase activity during early heart valve morphogenesis. We believe the EGFR family of receptors and cognate ligands play integral functions during heart development. This growth factor signaling activity is most likely context specific in regards to matrix components, proteases, and growth factor presence. Thus experimental approaches are designed to decipher this complex developmental process.
Enikov, Eniko: Biomaterials, Nano-assembly of macromolecules, AFM imaging of biomolecules. Development of micro-systems, MEMS and bioMEMS with application in biology and medicine.
Ghosh, Indraneel: The broad objective of our work is to use a repertoire of de novo protein design, directed evolution, and small-molecule approaches to target human disease.
Olenyuk, Bogdan: Recognition of cell surface receptors with synthetic macromolecules; Chemical control of cell adhesion and migration; Design of small molecules for control of protein levels via targeted degradation.
Saavedra, S. (Scott): Research interests include physical and chemical processes at solid-liquid interfaces, particularly those involving protein and proteo-lipid films; spectroscopic techniques to probe interfacial structure and processes; structure-property relationships in biomaterials and biological thin films; biomedical instrumentation, particularly optical waveguide transducers; analytical sensing devices based on biological thin films.

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